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Proteomic analysis of pubocervical fascia in women with and without pelvic organ prolapse and urodynamic stress incontinence

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Proteomic analysis of pubocervical fascia in women with and without pelvic organ prolapse and urodynamic stress incontinence
Athanasiou, Stavros Lymberopoulos, Elias Kanellopoulou, Sofia and Rodolakis, Alexandros Vlachos, George Antsaklis, Aris
scientific_publication_article
Επιστημονική δημοσίευση - Άρθρο Περιοδικού (EL)
Scientific publication - Journal Article (EN)
2010
Introduction and hypothesis This pilot study compares protein expression patterns in the pubocervical fascia of women with pelvic organ prolapse (POP) and stress urinary incontinence (SUI) and asymptomatic women with normal pelvic support methods Samples of pubocervical fascia were collected from four women with POP and SUI and from three asymptomatic (control) women These were analyzed using two-dimensional electrophoresis and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Results The expression levels of transgelin, smooth muscle gamma-actin, myosin light polypeptide 6, and alpha-1 antitrypsin precursor were more than twofold higher in patients than in controls An additional five proteins were overexpressed (more than twofold) in patients, while three proteins were detected only in the patients. Conclusion This pilot study is the first study to estimate changes in protein expression in the pubocervical fascia of human patients with POP. These changes could be related to the pathophysiology of POP (EN)
English
Ερευνητικό υλικό ΕΚΠΑ
https://creativecommons.org/licenses/by-nc/4.0/
University of Athens
Pergamos Digital Library
Journal Article



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