Effects of atorvastatin on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young subjects with successfully repaired coarctation of aorta
δείτε την πρωτότυπη σελίδα τεκμηρίου στον ιστότοπο του αποθετηρίου του φορέα για περισσότερες πληροφορίες και για να δείτε όλα τα ψηφιακά αρχεία του τεκμηρίου*
Effects of atorvastatin on endothelial function and the expression of
proinflammatory cytokines and adhesion molecules in young subjects with
successfully repaired coarctation of aorta
Brili, S.
Tousoulis, D.
Antonopoulos, A. S.
Antoniades, C.
and Hatzis, G.
Bakogiannis, C.
Papageorgiou, N.
Stefanadis,
C.
Objective To investigate the effects of atorvastatin on endothelial
function and low-grade systemic inflammation in subjects with successful
surgery for aortic coarctation repair (SCR).
Design Open-label study.
Setting Outpatients visiting the adult congenital heart disease
department of our hospital.
Patients 34 young people with SCR.
Interventions Patients with SCR received atorvastatin 10 mg/day (n=17)
or no treatment (n=17) for 4 weeks. At baseline and at 4 weeks,
endothelial function was assessed by flow-mediated dilatation (FMD) of
the right brachial artery, and blood samples were obtained. Serum levels
of interleukin (IL) 1b, IL-6 and soluble vascular cell adhesion
molecule-1 (sVCAM-1) were determined by ELISA.
Main outcome measures Effects of treatment on FMD and serum levels of
IL-1b, IL-6 and sVCAM-1.
Results FMD in the atorvastatin group was significantly improved after 4
weeks (from 6.46 +/- 0.95% to 11.24 +/- 1.38%, p<0.01), while
remaining unchanged in the control group (from 6.74 +/- 0.58% to 6.95
+/- 0.53%, p-NS). Even though atorvastatin had no effect on serum IL-6
levels (0.62 (0.37-0.88) pg/ml to 0.53 (0.28-0.73) pg/ml, p=NS), it
significantly reduced circulating levels of IL-1b (from 1.17 (0.92-1.77)
pg/ml to 1.02 (0.75-1.55) pg/ml, p<0.05) and sVCAM-1 (from 883.4
(660.3-1093.1) ng/ml to 801.4 (566.7-1030.2) ng/ml, p<0.05). No changes
were seen in serum levels of IL-6, IL-1b and sVCAM-1 in the control
group after 4 weeks compared with baseline (p=NS for all).
Conclusions Atorvastatin treatment for 4 weeks in subjects with SCR
significantly improved endothelial function and suppressed systemic
inflammatory status by decreasing circulating levels of IL-1b and
sVCAM-1.
(EN)
*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.
Effects of atorvastatin on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young subjects with successfully repaired coarctation of aorta
Effects of atorvastatin on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young subjects with successfully repaired coarctation of aorta
Βοηθείστε μας να κάνουμε καλύτερο το OpenArchives.gr.
Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
