δείτε την πρωτότυπη σελίδα τεκμηρίου στον ιστότοπο του αποθετηρίου του φορέα για περισσότερες πληροφορίες και για να δείτε όλα τα ψηφιακά αρχεία του τεκμηρίου*
Pattern of adrenal morphology and function in patients with acromegaly
Pappa, Theodora
Papanastasiou, Labrini
Koutmos, Spiros and
Tsiavos, Vaios
Roussaki, Peggy
Zilos, Athanasios
Ragkou,
Despina
Kaltsas, Gregory
Piaditis, George
Background Acromegaly is well known to induce hypertrophic and
hyperplastic changes in various organs and is commonly accompanied by
arterial hypertension. In our study, we assess the adrenal morphology
and function in a series of patients with acromegaly and possible
associations with the activity of the disease and arterial hypertension.
Materials and methods Sixty patients with acromegaly, admitted to two
endocrinology departments in the time period 2005-2010, were studied
prospectively. Basal IGF-1 and growth hormone levels after oral glucose
tolerance test were used to assess the disease activity. All subjects
underwent adrenal CT scan, basal adrenal hormonal investigation and
evaluation with 24-h urinary free cortisol and cortisol levels following
low-dose dexamethasone suppression test. In 33 acromegalics, the
modified saline infusion test (MSI), i.e. saline infusion after
dexamethasone administration, was performed to identify autonomous
aldosterone (ALD) secretion. Results Abnormal adrenal morphology was
present in 48% of our patients, and a significant association was found
between the presence of arterial hypertension and adrenal morphology.
Among patients with adrenal morphological changes, 55% exhibited no
adrenal secretory hyperactivity, 34% autonomous cortisol, 7% ALD and
4% combined autonomous cortisol and ALD secretion, when applying
recently proposed modified cut-off levels compared to widely used
criteria. An increased prevalence of autonomous ALD secretion was shown
among the subgroup of patients with acromegaly tested with MSI.
Conclusions This study provides evidence of an increased prevalence of
anatomic and functional adrenal alterations in patients with acromegaly;
further studies will clarify the importance of evaluating these subjects
with baseline hormonal investigation along with dynamic testing and
modified cut-offs.
(EN)
*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.
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