δείτε την πρωτότυπη σελίδα τεκμηρίου στον ιστότοπο του αποθετηρίου του φορέα για περισσότερες πληροφορίες και για να δείτε όλα τα ψηφιακά αρχεία του τεκμηρίου*
Sleep EEG and Spindle Characteristics After Combination Treatment With
Clozapine in Drug-Resistant Schizophrenia: A Pilot Study
Tsekou, Hara
Angelopoulos, Elias
Paparrigopoulos, Thomas and
Golemati, Spyretta
Soldatos, Constantin R.
Papadimitriou, George
N.
Ktonas, Periklis Y.
Purpose: Clozapine is an atypical neuroleptic agent, effective in
treating drug-resistant schizophrenia. The aim of this work was to
investigate overall sleep architecture and sleep spindle morphology
characteristics, before and after combination treatment with clozapine,
in patients with drug-resistant schizophrenia who underwent
polysomnography.
Methods: Standard polysomnographic techniques were used. To quantify the
sleep spindle morphology, a modeling technique was used that quantifies
time-varying patterns in both the spindle envelope and the intraspindle
frequency.
Results: After combination treatment with clozapine, the patients showed
clinical improvement. In addition, their overall sleep architecture and,
more importantly, parameters that quantify the time-varying sleep
spindle morphology were affected. Specifically, the results showed
increased stage 2 sleep, reduced slow-wave sleep, increased rapid eye
movement sleep, increased total sleep time, decreased wake time after
sleep onset, as well as effects on spindle amplitude and intraspindle
frequency parameters. However, the above changes in overall sleep
architecture were statistically non-significant trends.
Conclusions: The findings concerning statistically significant effects
on spindle amplitude and intraspindle frequency parameters may imply
changes in cortical sleep EEG generation mechanisms, as well as changes
in thalamic pacing mechanisms or in thalamo-cortical network dynamics
involved in sleep EEG generation, as a result of combination treatment
with clozapine. Significance: Sleep spindle parameters may serve as
metrics for the eventual development of effective EEG biomarkers to
investigate treatment effects and pathophysiological mechanisms in
schizophrenia.
(EN)
*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.
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