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The Effect of Probiotic Supplements on Metabolic Control of People with Type 2 Diabetes in Greece. A Randomized, Double-blind, Placebo-controlled Study

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The Effect of Probiotic Supplements on Metabolic Control of People with Type 2 Diabetes in Greece. A Randomized, Double-blind, Placebo-controlled Study
Eva Zikou Nikolas Dovrolis Charilaos Dimosthenopoulos Maria Gazouli Konstantinos Makrilakis
preprint
Εργασία εν εξελίξει (Preprint) (EL)
Preprint (EN)
2023
The role of probiotics supplementation in type 2 diabetes (T2D) treatment is controversial. The present study aimed to assess the effects of a multi-strain probiotic supplement [LactoLevureR (containing Lactobacillus Acidophilus, Lactobacillus plantarum, Bifidobacterium lactis, and Sac-charomyces boulardii)] over 6 months, on glycemic and lipid levels, as well as alterations in the gut microbiome, among individuals with T2D residing in Greece. A total of 91 adults with T2D (mean age [±SD] 65.12±10.92 years, 62.6% males) were randomized to receive the probiotic supplement or a matching placebo capsule, once daily, for 6 months. Blood chemistries and anthropometric pa-rameters were conducted every 3 months and stool samples were collected at baseline and 6 months. Significant reductions in HbA1c, fasting blood glucose and total cholesterol were observed in participants treated with the probiotics supplement (n=46) compared to the controls (n=45), even after adjustment for a greater decrease in adiposity (waist circumference). Although there were no statistically significant differences in the diversity of the gut microbiome (α- and β-diversity), the administration of probiotics did influence several genera, metabolites, and key enzymes associated with diabetes. Overall, the administration of the multi-strain probiotic LactoLevureR over a 6-month period in individuals with T2D was well-tolerated and had a positive impact on metabolic pa-rameters, alongside improvements in indices of adiposity. (EN)
Επιστήμες Υγείας
Επιστήμες Υγείας (EL)
Health Sciences (EN)
English
Σχολή Επιστημών Υγείας » Τμήμα Ιατρικής
https://creativecommons.org/licenses/by-nc/4.0/
University of Athens
Pergamos Digital Library
Preprint



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