The Effect of Probiotic Supplements on Metabolic Control of People with Type 2 Diabetes in Greece. A Randomized, Double-blind, Placebo-controlled Study
δείτε την πρωτότυπη σελίδα τεκμηρίου στον ιστότοπο του αποθετηρίου του φορέα για περισσότερες πληροφορίες και για να δείτε όλα τα ψηφιακά αρχεία του τεκμηρίου*
The Effect of Probiotic Supplements on Metabolic Control of People with Type 2 Diabetes in Greece. A Randomized, Double-blind, Placebo-controlled Study
Eva Zikou
Nikolas Dovrolis
Charilaos Dimosthenopoulos
Maria Gazouli
Konstantinos Makrilakis
The role of probiotics supplementation in type 2 diabetes (T2D) treatment is controversial. The present study aimed to assess the effects of a multi-strain probiotic supplement [LactoLevureR (containing Lactobacillus Acidophilus, Lactobacillus plantarum, Bifidobacterium lactis, and Sac-charomyces boulardii)] over 6 months, on glycemic and lipid levels, as well as alterations in the gut microbiome, among individuals with T2D residing in Greece. A total of 91 adults with T2D (mean age [±SD] 65.12±10.92 years, 62.6% males) were randomized to receive the probiotic supplement or a matching placebo capsule, once daily, for 6 months. Blood chemistries and anthropometric pa-rameters were conducted every 3 months and stool samples were collected at baseline and 6 months. Significant reductions in HbA1c, fasting blood glucose and total cholesterol were observed in participants treated with the probiotics supplement (n=46) compared to the controls (n=45), even after adjustment for a greater decrease in adiposity (waist circumference). Although there were no statistically significant differences in the diversity of the gut microbiome (α- and β-diversity), the administration of probiotics did influence several genera, metabolites, and key enzymes associated with diabetes. Overall, the administration of the multi-strain probiotic LactoLevureR over a 6-month period in individuals with T2D was well-tolerated and had a positive impact on metabolic pa-rameters, alongside improvements in indices of adiposity.
(EN)
*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.
Βοηθείστε μας να κάνουμε καλύτερο το OpenArchives.gr.
Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
