Qualitative and quantitative disturbances of lipid and lipoprotein metabolism in people with the metabolic syndrome

Η συσχέτιση του μεταβολικού συνδρόμου με ποιοτικές και ποσοστικές διαταραχές του μεταβολισμού των λιπιδίων και των λιποπρωτεϊνών

Qualitative and quantitative disturbances of lipid and lipoprotein metabolism in people with the metabolic syndrome

Gazi, Irene

Γαζή, Ειρήνη

PhD Thesis

2009

Over the last few years, there has been increasing interest regarding the constellation of metabolic disturbances that constitute the metabolic syndrome (MetSyn) which significantly increase the cardiovascular risk. These disturbances include an atherogenic lipid profile, increased blood pressure measurements and an altered carbohydrate metabolism. The prevalence of the MetSyn is rising rapidly worldwide, mostly due to the increased prevalence of obesity. The term HTGW syndrome is used for the identification of individuals with inceased TG levels and elevated WC. These individuals are characterised by the presence of the atherogenic metabolic triad, i.e. elevated serum levels of insulin, apoB and sdLDL particles. Moreover, individuals with the HTGW syndrome are at increased risk for cardiovascular disease (CVD) and new onset diabetes mellitus. Several clinical studies (both in healthy subjects as well as in patients with known CVD) have shown that increased Lp-PLA2 mass and/or activity is associated with elevated vascular risk. The purpose of the present study was to determine in detail the lipid profile of subjects with the MetSyn or the HTGW syndrome and compare it with that of individuals who did not fulfill the criteria for the diagnosis of the above mentioned syndromes. We emphasised on the evaluation of the sdLDL-C levels and the mean and peak LDL particle diameter using a new electrophoretic method (Lipoprint LDL System). Moreover, we assessed Lp-PLA2 activity and mass in total plasma, in HDL, as well as in lipoprotein subfractions. According to our results, MetSyn individuals exhibit increased levels of sdLDL-C and decreased mean and peak LDL particle size compared with subjects that do not fulfill the MetSyn criteria. SdLDL-C levels increase and LDL particle size decreases as the number of the criteria fulfilled rise. The major determinant of these disturbances is the concentration of TG in serum. Individuals with the HTGW syndrome are characterised by increased levels of VLDL-C and sdLDL-C and decreased LDL particle size compared with patients without the HTGW syndrome. SdLDL-C concentration increased and LDL particle size decreased with increasing serum levels of TG and WC measurements. Women with TG levels ?112 mg/dL and WC ?84.5 cm were 4-times more likely to exhibit the metabolic triad compared with women with one or none of these two parameters above the proposed cut-off points. Total plasma activity (but not mass) is the second best predictor of the presence of sdLDL particles in plasma (following serum TG levels). Finally, most of Lp-PLA2 mass is delivered on sdLDL particles. However, the enzyme activity is much less than that expected of its mass. In conclusion, MetSyn and HTGW individuals are characterised by a more atherogenic profile compared with subjects who do not fulfill the criteria for the diagnosis of these two syndromes. Total plasma Lp-PLA2 is the second best predictor of the presence of sdLDL particles, after serum TG levels.

Κλινική Ιατρική

Ιατρική και Επιστήμες Υγείας

Clinical Medicine

Lipoprotein-associated phospholipase A2

Μικρά πυκνά LDL σωματίδια

Medical and Health Sciences

Small dense LDL particles

Απολιποπρωτεΐνες

Κλινική Ιατρική

Μεταβολικό σύνδρομο

Metabolic syndrome

Apolipoproteins

Ιατρική και Επιστήμες Υγείας

Συνδεδεμένη με λιποπρωτεΐνια φωσφολιπάση Α2

Ελληνική γλώσσα

Πανεπιστήμιο Ιωαννίνων

University of Ioannina

Πανεπιστήμιο Ιωαννίνων. Σχολή Ιατρικής. Τμήμα Ιατρικής. Τομέας Παθολογικός. Κλινική Β' Παθολογική Πανεπιστημιακού Γενικού Νοσοκομείου Ιωαννίνων

Εθνικό Κέντρο Τεκμηρίωσης και Ηλεκτρονικού Περιεχομένου (ΕΚΤ)

Εθνικό Αρχείο Διδακτορικών Διατριβών

Συλλογή ΕΑΔΔ