The work lies on many scientific fields (civil engineering, architecture engineering, restoration and conservation science and materials science) cooperate to identify damage cases and damage assessment to historic traditional buildings and proposed adequate intervention methods to strengthening and rehabilitation of traditional buildings to re-use it in cultural job . 1st chapter: Historic traditional masonry structures; history, development and structural elements. In this chapter we study the historical and architectural development of historic traditional masonry buildings and the development of traditional masonry residential buildings in Athens-Greece and Cairo-Egypt; attention is focused on a comparative study of the architectural components which governed the design concept of Athens and Cairo traditional house and highlighted its distinctive characteristics, building materials used for structural elements, and deterioration phenomena. 2nd Chapter: Factors and aspects damage of historic traditional masonry. This chapter is concerned with a study of the deterioration factors and phenomena which may affect the integrity of historic traditional buildings. Such factors include earthquakes, change in uses and past conversion(s), structural (construction) defects, cracking, wall delamination, and the absence of conservation and restoration. 3rd Chapter: Structural appraisal; Registration, Documentation, and Testing methods. As for the structural appraisal of historic traditional masonry, the chapter discusses and explains the procedures adopted for structural appraisal. These procedures include registration and documentation, monitoring, testing methods and laboratory work. 4th Chapter: Rehabilitation Methods for Historic Traditional Masonry Building. In this part the work focused on studying the methods which used to improve structural behaviour of the historic traditional masonry buildings. These methods involve the strengthening of masonry walls, the improvement of the connections between walls and floors, the repair of floors. The study is concluded with a discussion on how to re-use historic traditional buildings 5thChapter: Case study. Aktaiou building was built in the early 19th century and it is considered to represent the structural and architectural trends prevailing in Athens this period and has suffered significant deterioration phenomena. The work was divided as follows: General description of the building, history of the building, archaeological studies, presents appraisal, deterioration phenomena and factors, present condition, damage assessment and identification of damage phenomena. The work was based on mechanical and chemical tests such as XRD, XRF, optical microscope, compression tests, strain gage measurements, study of the mechanical and physical properties and linking these properties with deterioration phenomena. Structural analysis of the building in both its initial state and after the implementation of the proposed interventions, identification of the causes of damage based on visual observation and mapping of the deterioration phenomena, numerical analysis. and verification of proposed intervention of Aktaiou building to resist different deterioration factors in the future.