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Η επίδραση της θεραπείας με LHRH ανάλογο στην ελαστικότητα των αγγείων και στην λειτουργικότητα του ενδοθηλίου σε ασθενείς με καρκίνο του προστάτη

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The effect of therapy with an LHRH analogue in vessel stiffness and in the endothelial function in patients with prostate cancer
Η επίδραση της θεραπείας με LHRH ανάλογο στην ελαστικότητα των αγγείων και στην λειτουργικότητα του ενδοθηλίου σε ασθενείς με καρκίνο του προστάτη
Mourmouris, Panagiotis
Μουρμούρης, Παναγιώτης
PhD Thesis
2014
Objective To study the effect of androgen deprivation therapy with an LHRH analogue in arterial stiffness and endothelial function of peripheral arteries as a possible mechanism increasing their cardiovascular riskMaterial- Methods This pilot study is a prospective analysis of 32 patients with metastatic prostate cancer who received Maximal Androgen Blockade. We evaluated the endothelial function of brachial artery through ultrasound and measurement of Flow Mediated Dilatation (FMD) and we assessed the central arterial stiffness of the aorta by measuring Augmentation index (AIX) and velocity of the aortic pulse wave (PWV). The measurements were performed one day before starting treatment and then three months and six months after the initiation of treatment.Results PWV increased significantly by 8, 26% from three to six months of follow up (p=0,037). FMD was found slightly elevated from baseline to 6 months of follow up by 7, 18% (p>0, 99), but AI was increased significantly (15, 53%, p=0,007) at six months as compared with baseline measures. Glucose, LDL, Triglycerides were increased by 15, 23% (p=0,002) 14, 34% (p<0,001), and 13, 46 %( p<0,001) respectively at 6 months follow up and these values increased significantly between all other time points. HDL was decreased statistically significantly by 14, 56 %( p<0,001) during the follow up of 6 months.Conclusions We found that these agents cause changes in arterial stiffness of the aorta and the endothelial function of peripheral arteries and we proposed them as a possible mechanism of increasing their cardiovascular risk
Ιατρική και Επιστήμες Υγείας ➨ Επιστήμες Υγείας
Ιατρική και Επιστήμες Υγείας ➨ Κλινική Ιατρική
LHRH analogue
Clinical Medicine
Επιστήμες Υγείας
Medical and Health Sciences
LHRH ανάλογο
Cardiovascular
Κλινική Ιατρική
Καρδιαγγειακό
Καρκίνος προστάτη
Prostate cancer
Ιατρική και Επιστήμες Υγείας
Health Sciences
Greek
National and Kapodistrian University of Athens
Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)
Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής. Τομέας Χειρουργικής. Κλινική Β' Ουρολογική Περιφερειακού Γενικού Νοσοκομείου Αττικής ΣΙΣΜΑΝΟΓΛΕΙΟ
National Documentation Centre (EKT)
National Archive of PhD Theses
Συλλογή ΕΑΔΔ



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