Synthesis of 4-(Fmoc-aminoacyloxymethyl)phenoxyacetic acids for use in solid-phase peptide synthesis

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Synthesis of 4-(Fmoc-aminoacyloxymethyl)phenoxyacetic acids for use in solid-phase peptide synthesis

Zinieris, N. Kokinaki, S. Leondiadis, L. Ferderigos, N.

scientific_publication_article
Επιστημονική δημοσίευση - Άρθρο Περιοδικού (EL)
Scientific publication - Journal Article (EN)

2006


The synthesis of 4-(Fmoc-aminoacyloxymethyl)phenoxyacetic acids was achieved in high yield by the reaction of Fmoc-amino acids with (4-iodomethylphenoxy)acetic acid 2-oxo-2-phenylethyl ester. The removal of the temporary protecting group, phenacyl ester, was effectively achieved by reductive cleavage with magnesium turnings. © Georg Thieme Verlag Stuttgart. (EN)

English

https://creativecommons.org/licenses/by-nc/4.0/




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