δείτε την πρωτότυπη σελίδα τεκμηρίου στον ιστότοπο του αποθετηρίου του φορέα για περισσότερες πληροφορίες και για να δείτε όλα τα ψηφιακά αρχεία του τεκμηρίου*
Neonatal leptin levels are strongly associated with female gender, birth
length, IGF-I levels and formula feeding
Petridou, E
Mantzoros, CS
Belechri, M
Skalkidou, A and
Dessypris, N
Papathoma, E
Salvanos, H
Lee, JH and
Kedikoglou, S
Chrousos, G
Trichopoulos, D
Objective To investigate predictors of circulating leptin in healthy
full-term newborns and to explore the relationship with anthropometric
variables, serum levels of adiponectin and the major components of the
IGF system at birth. To explore whether leptin levels are regulated by
breastfeeding vs. formula feeding.
Design Observational cross-sectional study.
Patients Three hundred and nineteen healthy full-term newborns delivered
during 1999 in Athens, Greece.
Measurements Anthropometric measurements, formula feeding information
and blood samples were obtained. Leptin and adiponectin determinations
were performed using a radioimmunoassay (RIA).
Results Multivariate regression analyses showed that leptin levels were
positively associated with female gender, newborn length, ponderal index
and IGF-I levels, but not with adiponectin levels. Newborns who were fed
exclusively with milk formulas had more than twice the leptin levels of
those who were exclusively breastfed.
Conclusions Leptin levels are positively related to female gender and
anthropometric characteristics of neonates but, contrary to studies in
adults, are not correlated with adiponectin levels. We also found
evidence that formula feeding imparts a considerable increase in leptin
levels in newborns.
(EN)
*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.
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