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Mechanisms of ketamine action on lipid metabolism in rats
Saranteas, T
Zotos, N
Lolis, E
Stranomiti, J
Mourouzis,
C
Chantzi, C
Tesseromatis, C
Background and objective: This study was conducted to determine the
effect of ketamine on metabolic homoeostasis and particularly in
lipoprotein lipase (LPL) activity in adipose tissue.
Methods: Sixty male Wistar rats were divided into six groups of 10 each.
Group A served as controls, while Groups B-F received, respectively,
ketamine 60, 80, 100, 120 and 140 mg kg(-1) intraperitoneally. The
animals were sacrificed 20 min after the administration of ketamine.
Insulin concentrations in plasma and total cholesterol, triglyceride,
high-density lipoprotein (HDL) and free fatty acid (FFA) concentrations
in serum were measured. LPL activity in adipose tissue and medium-chain
acyl-CoA dehydrogenase (MCAD) content in muscle were determined.
Results: FFA concentrations in serum significantly increased from the
second lowest dose of ketamine. Insulin concentrations in plasma did not
exhibit any significant difference between groups. MCAD levels were
0.5-fold more in Group F than in Group A, while there were no
significant differences between control group and Groups B-E.
Furthermore, high concentrations (120 and 140 mg kg(-1)) of ketamine
interfered with in metabolic homoeostasis by significantly reducing LPL
activity, thus elevating triglyceride concentrations in serum without
affecting cholesterol and HDL metabolism.
Conclusions: Ketamine induces various metabolic effects due to changes
in adipose LPL activity and MCAD levels in muscles. These findings seem
to be significant only at high doses.
(EN)
*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.
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