δείτε την πρωτότυπη σελίδα τεκμηρίου στον ιστότοπο του αποθετηρίου του φορέα για περισσότερες πληροφορίες και για να δείτε όλα τα ψηφιακά αρχεία του τεκμηρίου*
Comparative elution of moxifloxacin from Norian skeletal repair system
and acrylic bone cement: an in vitro study
Kanellakopoulou, Kyriaki
Tsaganos, Thomas
Athanassiou, Kalomira
and Koutoukas, Pantelis
Raftogiannis, Maria
Skiadas, Ioannis and
Giamarellou, Helen
The objective of this study was to evaluate the efficacy of Norian
skeletal repair system (SRS), a novel biodegradable and injectable form
of calcium phosphate cement with a composition similar to that of
cancellous bone, as a carrier for moxifloxacin, which is the most potent
quinolone agent against staphylococci and Enterobacteriaceae. Norian SRS
was mixed with moxifloxacin at a ratio of ca. 100:3 at room temperature
and solidified in the bottom of a cylindrical vial. The same procedure
was followed for acrylic bone cement. A total of five vials were
prepared per system. Mueller-Hinton broth was placed over the free
surface of both systems and the vials were transferred to a 37 degrees C
incubator. The broth was replaced daily until visual degradation of both
systems. Moxifloxacin was measured in aliquots of broth after passage
through a high-performance liquid chromatography system. Optical
degradation of both systems occurred after 450 days. Until Day 17,
concentrations eluted from both systems were similar. After Day 18 until
degradation, concentrations eluted by Norian SRS were statistically
higher than those eluted by acrylic bone cement and ranged between 100
mg/L and 800 mg/L. The mean area under the concentration-time curve
(AUC) over 450 days of sampling was 241 935.0 mg/L day for Norian SRS
and 18 300.0 mg/L day for the acrylic bone cement system (P = 0.043).
Norian SRS is a novel biodegradable system providing excellent strength
and mineralisation to bone. It was shown that this system allows in
vitro elution of moxifloxacin at significant concentrations, making it a
promising candidate for the therapy of chronic osteomyelitis. (c) 2006
Elsevier B.V. and the International Society of Chemotherapy. All rights
reserved.
(EN)
*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.
Comparative elution of moxifloxacin from Norian skeletal repair system and acrylic bone cement: an in vitro study
Comparative elution of moxifloxacin from Norian skeletal repair system and acrylic bone cement: an in vitro study
Βοηθείστε μας να κάνουμε καλύτερο το OpenArchives.gr.