δείτε την πρωτότυπη σελίδα τεκμηρίου στον ιστότοπο του αποθετηρίου του φορέα για περισσότερες πληροφορίες και για να δείτε όλα τα ψηφιακά αρχεία του τεκμηρίου*
Glucocorticoid action networks and complex psychiatric and/or somatic
disorders
Glucocorticoids contribute fundamentally to the maintenance of basal and
stress-related homeostasis in all higher organisms. These hormones
influence a large percentage of the expressed human genome and their
effects spare almost no organs or tissues. Glucocorticoids influence
many functions of the central nervous system, such as arousal,
cognition, mood and sleep, the activity and direction of intermediary
metabolism, the maintenance of a normal cardiovascular tone, the
activity and quality of the immune and inflammatory reaction, including
the manifestations of the sickness syndrome, as well as growth and
reproduction. The numerous actions of glucocorticoids are mediated by a
set of at least 16 glucocorticoid receptor (GR) isoforms forming homo-
or hetero-dimers. The GRs consist of multifunctional domain proteins
operating as ligand-dependent transcription factors that interact with
many other cell signaling systems. The presence of multiple GR monomers
and dimers expressed in a cell-specific fashion at different quantities
with quantitatively and qualitatively different transcriptional
activities suggests that the glucocorticoid signaling system is highly
stochastic. Based on ample evidence, we present our conception that
glucocorticoids are heavily involved in human pathophysiology and
influence life expectancy. Common psychiatric and/or somatic complex
disorders, such as anxiety, depression, insomnia, chronic pain and
fatigue syndromes, obesity, the metabolic syndrome, essential
hypertension, diabetes type 2, atherosclerosis with its cardiovascular
sequelae, and osteoporosis, as well as autoimmune inflammatory and
allergic disorders, all appear to have a glucocorticoid component.
(EN)
*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.
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