Corneal stromal demarcation line depth following standard and a modified high intensity corneal cross-linking protocol

Corneal stromal demarcation line depth following standard and a modified high intensity corneal cross-linking protocol

Kymionis, G.D. Tsoulnaras, K.I. Liakopoulos, D.A. Skatharoudi, C.A. Grentzelos, M.A. Tsakalis, N.G.

scientific_publication_article

Επιστημονική δημοσίευση - Άρθρο Περιοδικού (EL)

Scientific publication - Journal Article (EN)

2016

PURPOSE: To compare the corneal stromal demarcation line depth using anterior segment optical coherence tomography (AS-OCT) after corneal cross-linking (CXL) using two different treatment protocols: the standard Dresden protocol (30 minutes with 3 mW/cm2) and a modified high intensity protocol (7 minutes with 18 mW/cm2), corresponding to a total surface dose of 5.4 and 7.5 J/cm2, respectively. METHODS: This prospective, comparative, interventional case series included 29 keratoconic patients (32 eyes). All patients underwent CXL using the same high intensity ultraviolet-A (UV-A) irradiation device (CCL-365; Peschke Meditrade GmbH, Huenenberg, Switzerland). Sixteen eyes were treated for 30 minutes with 3 mW/cm2 according to the standard Dresden protocol, whereas 16 eyes were treated with a novel modified high intensity CXL protocol for 7 minutes with 18 mW/cm2 of UV-A irradiation intensity. One month postoperatively, corneal stromal demarcation line depth was measured by two independent observers using AS-OCT. RESULTS: There was no significant difference in corneal stromal demarcation line depth between observer measurements for both groups (P =.645, Dresden protocol group; P =.715, high intensity group). Mean corneal stromal demarcation line depth was 341.81 ± 47.02 μm for the Dresden protocol group and 313.37 ± 48.85 μm for the high intensity protocol group. There was no statistically significant difference (P =.104) in the corneal stromal demarcation line depth between the two groups. Mean endothelial cell density did not change significantly in either group (P =.090, Dresden protocol group; P =.103, high intensity group). No intraoperative or postoperative complications were noted. CONCLUSIONS: Corneal stromal demarcation line depth using UV-A irradiance with 3 mW/cm2 for 30 minutes and 18 mW/cm2 for 7 minutes was similar. It seems that the current modified accelerated CXL protocol provided the same treatment depth as the standard Dresden protocol. Copyright © SLACK Incorporated. (EN)

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Άρθρο Περιοδικού (Journal Article)