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β‐Endorphin serum levels in patients with vitiligo

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β‐Endorphin serum levels in patients with vitiligo
Katsambas, A.D. Schulpis, K.H. Antoniou, Ch. Rigopoulos, D. Papakostandinou, E.D. Stratigos, J.
scientific_publication_article
Επιστημονική δημοσίευση - Άρθρο Περιοδικού (EL)
Scientific publication - Journal Article (EN)
1994
Aim The aim of this study is to correlate the β‐endorphin levels at the early and more chronic stages of the disease in an attempt to find or confirm an etiological factor of vitiligo. Background The exact pathogenesis of vitiligo is still unclear. The most important theories are the self destruction, the autoimmune and the neural theories. Methods Patients with vitiligo (n= 28) were divided into two groups according to the duration of their disease. A group of 15 members of medical staff was the control group. β‐endorphin levels were determined with a radioimmunoassay (125I‐β‐endorphin IncstarCo). Results The mean β‐endorphin levels (11.88 ± 2.25 pmol/l) in patients at the early years of the disease (Group A) were statistically elevated compared to those of patients with ‘chronic’ vitiligo (9.27 ± 2.73 pmol/l) and to those of controls (8.53 ± 2.53) pmol/l). Conclusion We suggest that high β‐endorphin levels play a role in the pathogenesis of vitiligo as well as in the prognosis of the disease. Copyright © 1994, Wiley Blackwell. All rights reserved (EN)
English
Ερευνητικό υλικό ΕΚΠΑ
https://creativecommons.org/licenses/by-nc/4.0/
University of Athens
Pergamos Digital Library
Journal Article



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