δείτε την πρωτότυπη σελίδα τεκμηρίου στον ιστότοπο του αποθετηρίου του φορέα για περισσότερες πληροφορίες και για να δείτε όλα τα ψηφιακά αρχεία του τεκμηρίου*
The neuropsychiatry of multiple sclerosis: Focus on disorders of mood,
affect and behaviour
Paparrigopoulos, Thomas
Ferentinos, Panagiotis
Kouzoupis,
Anastasios
Koutsis, George
Papadimitriou, George N.
Neuropsychiatric symptoms are common in multiple sclerosis (MS). They
include two broad categories of disturbances: abnormalities in
cognition, and abnormalities of mood, affect and behaviour. The present
review deals with the epidemiology, clinical features, etiology and
treatment of disturbances included in the second category, i.e., major
depression, fatigue and sleep disorders, bipolar disorder, euphoria,
pathological laughing and crying, anxiety, psychosis and personality
changes. Major depression is one of the most common ncuropsychiatric
disorders in MS with an approximate 50% lifetime prevalence rate. Early
recognition and management of depression in MS is of major importance
because it is a key predictor of morbidity, mortality, quality of life,
possibly physical outcome and disease exacerbations, adherence to
immunomodulatory treatments and suicide risk in MS patients, as well as
of the caregiver’s distress and quality of life. The etiopathogenesis of
neuropsychiatric disorders in MS has been incompletely investigated. It
is postulated that a complex interplay of biological, disease-related,
behavioural and psychosocial factors contribute to the pathophysiology
of most of them. Management of neuropsychiatric symptoms in MS is often
effective, although commonly based on evidence provided by case studies
and uncontrolled trials. A comprehensive biopsychosocial
ncuropsychiatric approach is essential for the optimal care of patients
with MS.
(EN)
*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.
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