δείτε την πρωτότυπη σελίδα τεκμηρίου στον ιστότοπο του αποθετηρίου του φορέα για περισσότερες πληροφορίες και για να δείτε όλα τα ψηφιακά αρχεία του τεκμηρίου*
Decreased levels of alpha-synuclein in cerebrospinal fluid of patients
with clinically isolated syndrome and multiple sclerosis
Antonelou, Roubina Ch.
Emmanouilidou, Evangelia
Gasparinatos,
Gerasimos
Velona, Theodora
Voumvourakis, Konstantinos I. and
Stefanis, Leonidas
Cerebrospinal fluid (CSF) -synuclein (ASYN) levels are emerging as a
possible biomarker in a number of neurodegenerative conditions; however,
there has been little study of such levels in demyelinating conditions
with neurodegeneration such as multiple sclerosis (MS). In this study,
we aimed to assess CSF ASYN levels in MS spectrum [clinically isolated
syndrome (CIS) and MS] patients and compare them to those obtained in
control subjects with benign neurological conditions (BNC). We used a
recently developed, ultra-sensitive sandwich enzyme-linked immunosorbent
assay to measure and compare CSF ASYN levels in three categories of
subjects: BNC (n=38), CIS (n=36) and MS [Relapsing Remitting (RRMS,
n=22) and Primary Progressive (PPMS, n=15)]. We also performed secondary
analyses, including relationship of CSF ASYN levels to aging, gender,
presence of CSF oligoclonal bands (OB) and gadolinium (Gd)-enhancing
demyelinating lesions on T1-weighted MRIs. CSF ASYN levels were found to
be significantly lower in the CIS (78.27.5pg/mL), RRMS (76.8 +/-
5.1pg/mL), and PPMS (76.3 +/- 6.7pg/mL) groups compared to the BNC
(125.7 +/- 13.6pg/mL) group. Secondary analyses did not reveal
additional correlations. Our results suggest that in a cohort of CIS and
MS patients, CSF ASYN levels are decreased, thus providing another
possible link between MS and neurodegeneration. Future studies will need
to be performed to confirm and extend these findings, to lead to a
fuller understanding of the possible biological link between ASYN and
MS.
(EN)
*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.
Decreased levels of alpha-synuclein in cerebrospinal fluid of patients with clinically isolated syndrome and multiple sclerosis
Decreased levels of alpha-synuclein in cerebrospinal fluid of patients with clinically isolated syndrome and multiple sclerosis
Βοηθείστε μας να κάνουμε καλύτερο το OpenArchives.gr.