δείτε την πρωτότυπη σελίδα τεκμηρίου στον ιστότοπο του αποθετηρίου του φορέα για περισσότερες πληροφορίες και για να δείτε όλα τα ψηφιακά αρχεία του τεκμηρίου*
25-hydroxyvitamin D in malignant pleural disease: a prospective cohort
study
Panagiotou, Marios
Papaioannou, Andriana I.
Kostikas,
Konstantinos
Takou, Anna
Paraskeva, Maria
Kalkanis,
Alexandros
Diamantea, Filia
Kastanakis, Emmanuil
Maropoulos,
George
Filaditaki, Vasiliki
Karagianidis, Napoleon
IntroductionGrowing evidence suggests a role of vitamin D in various
cancers but the significance of vitamin D in malignant pleural disease
remains unexplored. We sought to investigate the concentration and
diagnostic role of 25-hydroxyvitamin D (25(OH)D) in malignant pleural
effusions.
Materials and MethodsProspective study of consecutive treatment-naive
patients with a new diagnosis of pleural effusion.
ResultsSeventy-eight patients were studied, 45 of whom had malignant
pleural effusions. Concentration of 25(OH)D in pleural fluid was
significantly higher than serum in both malignant (15.2 ng/mL (9.7,
25.6) versus 10.2 ng/mL (6.4, 17.7), P<.001) and benign (11.4 ng/mL
(8.4, 23.6) versus 7.9 (5.9, 16.1), P<.001) pleural disease. Pleural
fluid 25(OH)D was almost significantly higher in exudates compared to
transudates (P=.050) but it did not differ significantly between
malignant and benign effusions (P=.217) and it was not diagnostic for
malignant pleural disease (area under the ROC curve .58, 95% CI
.45-.71).
ConclusionsIn subjects with unselected pleural effusions, 25(OH)D in
pleural fluid was not diagnostic for malignant pleural disease. The
novel finding of convincingly and consistently higher 25(OH)D in pleural
fluid than serum suggests a role for vitamin D in pleural disease and
merits further research.
(EN)
*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.
25-hydroxyvitamin D in malignant pleural disease: a prospective cohort study
25-hydroxyvitamin D in malignant pleural disease: a prospective cohort study
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