δείτε την πρωτότυπη σελίδα τεκμηρίου στον ιστότοπο του αποθετηρίου του φορέα για περισσότερες πληροφορίες και για να δείτε όλα τα ψηφιακά αρχεία του τεκμηρίου*
Regressions of Clustered Gene Expression Data Manifest Tumor-Specific
Genes in Urinary Bladder Cancer
Sarafidis, Michail
Zaravinos, Apostolos
Iliopoulou, Dimitra and
Koutsouris, Dimitrios
Lambrou, George I.
Bladder cancer or urinary bladder cancer, is a common neoplasm of the
urinary tract, with higher prevalence in men aged 60 to 70 years. In the
present work we have used gene expression microarray data both from
in-house experimentation, as well as from publicly available microarray
data. We have used bioinformatics analyses as well as regression
methodologies, in order to find common gene expression profiles with
respect to tumor subtypes and differentiation. Our approach included
gene clustering with k-means, and gene functional annotation. We have
found several gene groups that manifest common expression profiles and
also we have identified clusters of genes that manifested an ascending
or descending pattern with respect to tumor differentiation and subtype.
Such approaches could prove useful to the identification of noel gene
targets that could be utilized as prognostic, diagnostic and therapeutic
targets.
(EN)
*Η εύρυθμη και αδιάλειπτη λειτουργία των διαδικτυακών διευθύνσεων των συλλογών (ψηφιακό αρχείο, καρτέλα τεκμηρίου στο αποθετήριο) είναι αποκλειστική ευθύνη των αντίστοιχων Φορέων περιεχομένου.
Regressions of Clustered Gene Expression Data Manifest Tumor-Specific Genes in Urinary Bladder Cancer
Regressions of Clustered Gene Expression Data Manifest Tumor-Specific Genes in Urinary Bladder Cancer
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