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25-hydroxyvitamin D in malignant pleural disease: a prospective cohort study

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25-hydroxyvitamin D in malignant pleural disease: a prospective cohort study
Panagiotou, Marios Papaioannou, Andriana I. Kostikas, Konstantinos Takou, Anna Paraskeva, Maria Kalkanis, Alexandros Diamantea, Filia Kastanakis, Emmanuil Maropoulos, George Filaditaki, Vasiliki Karagianidis, Napoleon
scientific_publication_article
Επιστημονική δημοσίευση - Άρθρο Περιοδικού (EL)
Scientific publication - Journal Article (EN)
2018
IntroductionGrowing evidence suggests a role of vitamin D in various cancers but the significance of vitamin D in malignant pleural disease remains unexplored. We sought to investigate the concentration and diagnostic role of 25-hydroxyvitamin D (25(OH)D) in malignant pleural effusions. Materials and MethodsProspective study of consecutive treatment-naive patients with a new diagnosis of pleural effusion. ResultsSeventy-eight patients were studied, 45 of whom had malignant pleural effusions. Concentration of 25(OH)D in pleural fluid was significantly higher than serum in both malignant (15.2 ng/mL (9.7, 25.6) versus 10.2 ng/mL (6.4, 17.7), P<.001) and benign (11.4 ng/mL (8.4, 23.6) versus 7.9 (5.9, 16.1), P<.001) pleural disease. Pleural fluid 25(OH)D was almost significantly higher in exudates compared to transudates (P=.050) but it did not differ significantly between malignant and benign effusions (P=.217) and it was not diagnostic for malignant pleural disease (area under the ROC curve .58, 95% CI .45-.71). ConclusionsIn subjects with unselected pleural effusions, 25(OH)D in pleural fluid was not diagnostic for malignant pleural disease. The novel finding of convincingly and consistently higher 25(OH)D in pleural fluid than serum suggests a role for vitamin D in pleural disease and merits further research. (EN)
English
Ερευνητικό υλικό ΕΚΠΑ
https://creativecommons.org/licenses/by-nc/4.0/
University of Athens
Pergamos Digital Library
Journal Article



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