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9,11-Secosterols with antiproliferative activity from the gorgonian Eunicella cavolini

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9,11-Secosterols with antiproliferative activity from the gorgonian Eunicella cavolini
Roussis, Vassilios
Vagias, Constantinos
Alexi, Xanthippi
Αλέξης, Μιχαήλ Ν.
Ioannou, Efstathia
Abdel-Razik, Ayman F.
Άρθρο σε επιστημονικό περιοδικό
2009-07-01
OXFORD
Four new 9,11-secosterols (2, 4-6), along with two previously reported ones (1, 3) were isolated from the organic extract of the gorgonian Eunicella cavolini. The structures and relative configurations of the isolated natural products were established on the basis of detailed NMR spectroscopic analysis. Metabolites 1 and 2 were found to strongly inhibit the growth of LNCaP human prostate adenocarcinoma cells and the estrogen-dependent growth of MCF-7 human breast adenocarcinoma cells.
Οργανική χημεία (EL)
Βιολογία (Γενικά) (EL)
Χημεία (Γενικά) (EL)
Φαρμακευτική (EL)
Biology (General) (EN)
Organic chemistry (EN)
Pharmacy and materia medica (EN)
Chemistry (General) (EN)
Antiproliferative activity
Eunicella cavolini
Chemistry, Medicinal
Structure elucidation
9,11-Secosterols
English
Pergamon
Bioorganic & Medicinal Chemistry
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© 2009 Elsevier Ltd. All rights reserved.
© 2009 Elsevier Ltd. All rights reserved. (EN)
National Hellenic Research Foundation (NHRF)
Helios - Repository of the National Hellenic Research Foundation (NHRF)



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